Asymmetric Catalytic Transformations of Aza‐ortho‐ and Aza‐para‐Quinone Methides

Aza-quinone methides (aza-QMs) are transient intermediates, which are able to react easily with a variety of nucleophiles providing a variety of N-heterocycles. The catalytic methodologies for the derivatization of aza-QM into chiral derivatives have been recently reported and involve organocatalytic or organometallic approaches. This review aims at analyzing the diverse catalytic systems involving organo or metal catalysis for the transformation of aza-o-QM and aza-p-QM.

Abstract

The catalytic methodologies for the derivatization of aza-QM have recently appeared in the literature and involve organocatalytic and organometallic approaches. This review aims at analyzing the diverse catalytic systems involving chiral NHC carbenes, phosphoric acids, phosphoramidites, phosphine and copper and palladium catalysis showing its applicability for the synthesis of a diverse away of N-containing compounds which in many cases have biological activity.

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