Oleate hydratases convert oleic acid into 10-hydroxy stearic acid, a valuable fine chemical, useful in lubricant and surfactant formulations. They are of large interest due to their high expression rates and solubility, however, they differ drasti...
Asymmetric Catalytic Transformations of Aza‐ortho‐ and Aza‐para‐Quinone Methides
Von Wiley-VCH zur Verfügung gestellt
Aza-quinone methides (aza-QMs) are transient intermediates, which are able to react easily with a variety of nucleophiles providing a variety of N-heterocycles. The catalytic methodologies for the derivatization of aza-QM into chiral derivatives have been recently reported and involve organocatalytic or organometallic approaches. This review aims at analyzing the diverse catalytic systems involving organo or metal catalysis for the transformation of aza-o-QM and aza-p-QM.
The catalytic methodologies for the derivatization of aza-QM have recently appeared in the literature and involve organocatalytic and organometallic approaches. This review aims at analyzing the diverse catalytic systems involving chiral NHC carbenes, phosphoric acids, phosphoramidites, phosphine and copper and palladium catalysis showing its applicability for the synthesis of a diverse away of N-containing compounds which in many cases have biological activity.Zum Volltext
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