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Asymmetric Bio‐epoxidation of Unactivated Alkenes

Von Wiley-VCH zur Verfügung gestellt

The asymmetric epoxidation reactions of a variety of unactivated alkenes, including aliphatic chain olefins, cyclic olefins, and aromatic olefins, have been widely studied. This review lists three main types of engineered enzymes for the epoxidation reaction of unactivated alkenes, and discusses their substrate preference, regioselectivity and stereoselectivity.


Optically active epoxides play important roles in pharmaceutical, agricultural and fine chemical syntheses. There are many chiral medications with pharmacodynamic activity in nature that can be synthesized by chiral epoxides. In recent years, researchers have developed a variety of biocatalysts for the asymmetric epoxidation of alkenes, which use oxygen or hydrogen peroxide as eco-friendly and low-cost oxidants, to provide better chemo-, regio- and stereoselectivity under moderate reaction conditions. In this paper, the advances, opportunities and challenges of the asymmetric epoxidation of unactive alkenes by biocatalyst are reviewed.

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