The Front Cover shows a Co(II) ion that is actually chelated by two monoanionic sulfur-containing Schiff base ligands. Each ligand contributes with a nitrogen and an oxygen atom to form the illustrated pseudo-tetrahedral coordination. A ma...
α‐Acrylaldehyde 3‐Pyrrolyl BODIPY as a Specific Optical Sensor for Cysteine and Homocysteine
Von Wiley-VCH zur Verfügung gestellt
We synthesized α-acrylaldehyde 3-pyrrolyl BODIPY and used it as an optical probe for the selective detection of Cys and Hcy among other amino acids. The probe also helps in differentiating Cys from Hcy since the probe forms two different types of products upon reaction with Cys and Hcy.
A new fluorophore, α-acrylaldehyde 3-pyrrolyl BODIPY was synthesized by treating 3-pyrrolyl BODIPY with a mixture of 3-(dimethylamino) acrolein and POCl3 under Vilsmeier–Haack reaction conditions. The X-ray structure revealed that the fluorophore was almost planar, and the appended pyrrole was in the same plane with a small deviation from the mean plane. We investigated the potential use of α-acrylaldehyde 3-pyrrolyl BODIPY for sensing thiol containing amino acids such as cysteine/homocysteine (Cys/Hcy). Our studies showed that the α-acrylaldehyde- 3-pyrrolyl BODIPY was found to be useful for exclusive sensing of Cys/Hcy and to exhibit different optical signaling responses to Cys and Hcy at physiological pH in aq. CH3CN (1 : 1 v/v, PBS) medium. The enhancement in optical properties for Cys and quenching in same properties for Hcy was attributed to different binding modes of Cys/Hcy with α-acrylaldehyde 3-pyrrolyl BODIPY.Zum Volltext
Jetzt nächsten Artikel lesen:
Überprüfung Ihres Anmeldestatus ...
Wenn Sie ein registrierter Benutzer sind, zeigen wir in Kürze den vollständigen Artikel.