Direct amination of benzene is demonstrated with a plasma microreactor. Using ammonia plasma, this process was optimized by studying the influence of temperature, residence time and power of the plasma. Various compounds were evaluated to study i...
Artikel
A Tetradentate Ligand Enables Iron‐Catalyzed Asymmetric Hydrogenation of Ketones in a CO‐ or Isocyanide‐Free Fashion
Von Wiley-VCH zur Verfügung gestellt
A ferrocene-based tetradentate ligand featured with modular synthesis and rigid skeleton was reported. Its iron(II) complex facilitates asymmetric direct hydrogenation of ketones without the participation of extra strong-field ligand such as CO and isocyanide. Various chiral alcohols including the intermediate for montelukast could be prepared with satisfactory yields and enantioinduction.
Abstract
We herein reported the design and synthesis of a ferrocene-based tetradentate ligand that is featured with modular synthesis and rigid skeleton. Its iron(II) complex facilitates asymmetric direct hydrogenation of ketones without the participation of extra strong-field ligand such as CO and isocyanide. Hydride donor lithium aluminum hydride (LAH) converted non-reactive Fe(II) species to reactive Fe(II) hydride species. With this catalyst, various chiral alcohols including the intermediate for montelukast could be prepared with satisfactory yields and enantioinduction.
Zum VolltextÜberprüfung Ihres Anmeldestatus ...
Wenn Sie ein registrierter Benutzer sind, zeigen wir in Kürze den vollständigen Artikel.