A novel iron-catalyzed trifluoromethylation of indole-tethered alkene with Togni’s reagent to construct CF3-containing spiro[indole-3,3’-pyrrolidine] and tetrahydrocarbazole derivatives under mild and convenient conditions has been disclosed. The ...
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Visible‐Light‐Promoted Reaction of N‐Hydroxyphthalimide Esters with Vinyl Boronic Pinacol Ester
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A light-driven protocol to access alkyl boronic acid pinacol esters from vinyl boronate using N-hydroxyphthalimide esters as the alkyl generator was developed. A good substrate scope was examined, demonstrating good to high yields and excellent functional group tolerance.
Abstract
A novel and easy-to-execute light-driven protocol for the preparation of alkyl boronic acid pinacol esters from vinyl boronate using N-hydroxyphthalimide esters as the potential precursor is described. In this photochemical protocol, the N-hydroxyphthalimide ester's fragmentation generates C-centered radicals, which undergo a radical Michael addition to vinyl boronic pinacol ester furnishing the desired products. A good substrate scope having various functionalities is presented and good to high yields are obtained.
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