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Visible Light‐induced Decarboxylative Alkylations Enabled by Electron Donor‐Acceptor Complex

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A versatile protocol for visible-light-induced decarboxylative alkylations enabled by electron-donor acceptor complex has been reported. An array of primary, secondary, tertiary and amino acid-derived redox-active esters, Katritzky's salt and Togni's reagent were all amenable substrates to be coupled with a diverse range of nucleophiles, creating diverse C(sp3)−C(sp3) and C(sp3)−C(sp2) bonds with high efficiency.


Abstract

We demonstrated herein a versatile protocol for visible-light-induced decarboxylative alkylations enabled by electron-donor acceptor complex. An array of primary, secondary, tertiary and amino acid-derived redox-active esters (RAEs) were all amenable substrates to undergo radical decarboxylation to be coupled with a diverse range of nucleophiles, creating diverse C(sp3)−C(sp3) and C(sp3)−C(sp2) bonds with high efficiency. It is worth noting that Katritzky's salt and Togni's reagent were also suitable substrates, affording deaminative alkylation and trifluoromethylation products in high yields. Additionally, a one-pot two-step telescoped procedure and continuous-flow process further increase the synthetic utility of this catalytic system.

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