Synthetic Approaches to α‐, β‐, γ‐, and δ‐Lycoranes

This review compiles the current synthetic approaches toward lycoranes. Particularly, all those synthetic approaches gave access to α-lycorane (19 routes), β-lycorane (10 routes), γ-lycorane (38 routes), and δ-lycorane (6 routes), with 15 different routes reporting asymmetric total synthesis, mainly taking advantage of organocatalysts and transition metals.

Abstract

Lycorane is a pentacyclic core presented in alkaloids isolated from the Amaryllidaceae family of herbaceous flowering plants. Members of this class of natural products have shown to display important biological properties including analgesic, antiviral, and antiproliferative activities. This review presents the known synthetic routes toward α-, β-, γ-, and δ-lycoranes. α-(19 routes), β-(10 routes), γ-(38 routes), and δ-(6 routes).

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