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Synthesis of 5‐Substituted‐1H‐Tetrazoles from Nitriles and Azides in a Betaine‐Diol‐Based Deep Eutectic Solvent

Von Wiley-VCH zur Verfügung gestellt

Devising a simple, green, and reusable route for the [3+2] cycloaddition reaction of azides and nitriles to form tetrazoles is undoubtedly a challenging issue. Herein, a facile synthesis of 5-substituted-1H-tetrazoles was developed by treating nitriles with NaN3 in a betaine-diol-based deep eutectic solvent. This protocol offers products with high yields, an easy work-up procedure devoid of harmful organic solvents, and recyclability of the deep eutectic solvent, thereby making it environmentally benign.


Abstract

Devising a simple, environmentally friendly, and reusable route for the [3+2] cycloaddition reaction of azides and nitriles to form tetrazoles is undoubtedly a challenging issue. Herein, a facile synthesis method for 5-substituted-1H-tetrazoles was developed by treating nitriles with NaN3 in a betaine-diol-based deep eutectic solvent. This protocol offers products in very high yields, an easy work-up procedure devoid of harmful organic solvents, and recyclability of the deep eutectic solvent, thereby making it environmentally benign.

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