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Synergistic Approach for Decarboxylative Ortho C−H Aroylation of 2‐Aryl‐pyrido[1,2‐a]pyrimidin‐4‐ones and Thiazolopyrimidinones by Merging Palladium Catalysis with Photocatalysis

Von Wiley-VCH zur Verfügung gestellt

Synergistic merging of palladium catalysis and photoredox catalysis for mild and efficient decarboxylative C−H aroylation of pyrido[1,2-a]pyrimidin-4-one having intrinsic directing group at room temperature in excellent yield with good functional group tolerance.


Abstract

A mild and efficient synergistic approach for decarboxylative aroylation of 2-aryl-pyrido[1,2-a]pyrimidin-4-ones having intrinsic directing group has been developed by merging of palladium catalysis and photoredox catalysis at room temperature. Therapeutically interesting aryl ketones of pyrido[1,2-a]pyrimidin-4-one have been synthesized in good to excellent yield with good functional group tolerance.

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