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Selective Monoethynylation of 2‐Oxoacetamides Using Calcium Carbide as a Concise Solid Alkyne Source

Von Wiley-VCH zur Verfügung gestellt

Multifunctional compounds, 2-hydroxybut-3-ynamides, are selectively synthesized using inexpensive and easy-to-handle solid calcium carbide as an alkyne source instead of inflammable and explosive gaseous acetylene through monoethynylation of 2-oxoacetamides.


Abstract

An efficient selective monoethynylation of 2-oxoacetamides using calcium carbide as a concise solid alkyne source is described. A series of multifunctional compounds, 2-hydroxybut-3-ynamides, are synthesized by this strategy. The salient features of this protocol are the use of inexpensive and easy-to-handle solid alkyne source as a surrogate of inflammable and explosive gaseous acetylene, transition-metal-free and mild condition, wide scope of substrates, high selectivity, high yield, and simple work-up procedure.

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