Palladium‐catalyzed Asymmetric Oxycarbonylation of Internal Z‐Alkenes

The first enantioselective acetoxycarbonylation of internal Z-alkenes was presented, featuring with a sterically hindered Quinox ligand. The desired acetoxyester products were obtained in moderate to good yields and excellent enantioselectivities with good functional groups compatibility. Further transformations of these acetoxyesters into bioactive molecules and natural product analogs demonstrated the synthetic utility and application of this method.

Abstract

Herein we reported the first enantioselective acetoxycarbonylation of internal (Z)-alkenes, featuring with a sterically hindered Quinox ligand. The desired acetoxyester products, which could be easily transformed into various biologically important molecules, were obtained in moderate to good yields and excellent enantioselectivities, along with good functional groups compatibility. Further transformations of these acetoxyesters into natural product analogous demonstrated the synthetic utility and application of this method.

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