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Palladium‐Catalyzed Arylfluorination of Alkenes: A Powerful New Approach to Organofluorine Compounds

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Multitasking: One of the newly developed methods for accessing organofluorine compounds is Pd-catalyzed arylfluorination, which simultaneously introduces an aryl group and a fluorine atom into an olefin framework. This review provides a concise overview of this powerful and versatile method.


Abstract

Fluorine incorporation into organic molecules is often beneficial to their absorption, distribution, metabolism, and excretion (ADME) properties or bioactivity. As a consequence, organofluorine compounds have become quite common amongst drugs and agrochemicals, and their preparation is a highly important topic in both synthetic organic chemistry and pharmaceutical chemistry. One of the newly developed methods for accessing organofluorine compounds is Pd-catalyzed arylfluorination of alkenes. It is an olefin difunctionalization process that simultaneously introduces an aryl group and a fluorine atom into an alkene framework. This review provides a concise overview of this powerful and versatile method.

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