The depletion of finite primary fossil fuels makes necessary a progressive transition from finite primary fossil sources to alternative renewable raw materials to produce high value chemicals important for our everyday life. Greener processes mus...
Artikel
Oxetane Ring‐Opening Reaction: A Key Step for the Preparation of Substituted (Fluoro)alkenyl as Acyclonucleoside Mimics
Von Wiley-VCH zur Verfügung gestellt
An oxetane ring-opening reaction was achieved selectively to afford geometry-controlled tri- and tetrasubstituted alkenes as acyclonucleosides precursors. Preliminary enzymatic essays suggest a similarity between nucleosides and obtained fluoroacyclonucleosides.
Abstract
Tri- and tetra-substituted alkenes, including fluoroalkenes, were prepared by a selective ring-opening reaction of functionalized oxetanes. The introduction of adenine nucleic base allows the synthesis of alkenyl and fluoroalkenyl derivatives that were evaluated towards DltA enzyme as potential nucleoside mimics.
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