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Organocatalytic Asymmetric Reaction between α‐Cyano Enones and Dioxindoles: Synthesis of Dihydrofuran‐Spirooxindoles

Von Wiley-VCH zur Verfügung gestellt

An organocatalytic enantioselective synthesis of dihydrofuran-spirooxindole has been developed. The spirooxindole products were isolated in good to high yields with high diastereo- and enantioselectivities under mild and operationally simple reaction conditions.


Abstract

An organocatalytic enantioselective synthesis of dihydrofuran-spirooxindoles has been developed. Dioxindoles and trans-α-cyano-α,β-unsaturated ketones were engaged as the reaction partners in this method. The desired products were obtained via bifunctional squaramide catalyzed Michael reaction followed by Pinner reaction and isomerization.

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