The first synthesis of praziquantel was in 1972 – almost 50 years ago. In 1980 the compound was approved for the treatment of human Schistosomiasis and is still the drug of choice. This review summarizes the complex pharmacology of praziqu...
Artikel
Materials for Controlled Release of Local Anesthetics
Von Wiley-VCH zur Verfügung gestellt
Painless: We discuss the design considerations and material properties of systems for the controlled release of local anesthetics, covering a wide range of systems, from simple physical encapsulation to on-demand local anesthetics triggered by external stimuli.
Abstract
Controlled release systems for prolonged duration local anesthesia have long been an area of research interest, and now are entering clinical practice, in part driven by the opioid epidemic. We discuss the design considerations and material properties of systems for controlled release of local anesthetics, from relatively simple systems to covalent binding of drugs to materials and delivery triggered by external stimuli.
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