Controlled protein degradation by the ubiquitinproteasome pathway is critical for almost all cellular processes. E3 ubiquitin ligases are responsible for targeting proteins for ubiquitylation and subsequent proteasomal degradation with spatial and...
Artikel
Jointly Depleting Glutathione based on Self‐assembled Nanomicelles for Enhancing Photodynamic Therapy
Von Wiley-VCH zur Verfügung gestellt
Photodynamic therapy (PDT) is one common ROS-generating therapeutic method with high tumor selectivity and low side effects. But the GSH-upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self-assembly method from GSH-activated photosensitizer DMT, curcumin and amphiphilic polymer TPGS.
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