An efficient asymmetric direct vinylogous conjugate addition of α,β-unsaturated γ-butyrolactam to benzoyl acrylonitriles using thiourea organocatalyst is described. The reaction produced chiral δ-cyano-α,β-unsaturated γ-butyrolactam with g...
Artikel
Halogen‐Substituted Mesoionic‐Carbene/Palladium Complexes for Catalytic Arylation of Aldehydes
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The halogenated mesoionic-carbene-coordinated palladium complexes (TAPs/e-TAPs) were synthesized and acted as the catalyst for the arylation of aldehydes using arylboron compounds. Among them, 1-(2-bromophenyl)-1,2,3-triazolidene (η3-allyl)palladium chloride (Br-e-TAP) promoted the arylation most efficiently.
Abstract
Various halogenated mesoionic-carbene (MIC)-coordinated palladium complexes (denoted as TAPs and e-TAPs) were prepared using triazolylidene precursors that were synthesized in only two steps via a click reaction. Among the prepared complexes, 2-Bromophenyl group substituted e-TAP (Br-e-TAP) showed optimal catalytic activity for the arylation of aldehydes with arylboronic compounds. Additionally, the Br-e-TAP catalyst assisted in synthesizing a wide range of functionalized diarylmethanols and arylmethanols in 29–95% yields with loadings of 0.2–0.6 mol% Pd.
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