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Flexible Single‐Chain‐Heteropolymer‐Derived Transmembrane Ion Channels with High K+ Selectivity and Tunable pH‐Gated Characteristics

Von Wiley-VCH zur Verfügung gestellt

A series of single-chain random heteropolymer (RHP)-based artificial transmembrane ion channels were prepared via facile “one-pot” polymerization. K+ could be preferably recognized and transported through the nanopores formed by the aligned crown ethers on RHPs. Through simple modification, the RHP-derived potassium channels manifested satisfactory membrane compatibility, high K+ selectivity, and controllable pH-gated behaviors.


A series of single-chain random heteropolymer (RHP)-derived artificial ion channels with both high K+ selectivity and controllable pH-gated behaviors were fabricated by a facile “one-pot” polymerization method. The benzo-18-crown-6 moieties appended on lateral chains of RHPs can form ion-permeable nanopores and transport K+ over Na+ through the lipid bilayers. The ion permeation selectivity was significantly enhanced by incorporating a cholesterol group to serve as a membrane anchor. Interestingly, similar to natural gated protein channels, on–off switchable characteristics were also realized by integrating an additional acid-sensitive alkylamine group into the RHP-derived channel. The unique design strategies have endowed the RHP-derived ion channels with facile synthetic procedures, desirable membrane compatibility, high K+ selectivity, and tunable pH-gated properties. This work provides an entry point for future design of novel functional nanochannels.

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