The first enantioselective acetoxycarbonylation of internal Z-alkenes was presented, featuring with a sterically hindered Quinox ligand. The desired acetoxyester products were obtained in moderate to good yields and excellent enantioselect...
Artikel
Facile Construction of Functionalized 4H‐Chromene Scaffolds via Sn(OTf)2‐Catalyzed C−H Functionalization/Cyclization Reaction and Ir‐Catalyzed Direct C−H Amidation
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A sequential Sn(OTf)2-catalyzed Friedel–Crafts type C−H functionalization/cyclization process for the formation of 4H-chromene scaffolds from naphthols and conjugated diketones has been described. A series of amino-modified 4H-chromene compounds were afforded through Ir-catalyzed C−H amination with the assistance of the carbonyl as a weak directing group.
Abstract
An efficient strategy for the construction of 4H-chromene scaffolds from naphthols and conjugated diketones through a sequential Sn(OTf)2-catalyzed Friedel–Crafts type C−H functionalization/cyclization process has been described. The Ir-catalyzed C−H amination of these products could also be performed with the assistance of the carbonyl as a weak directing group, which produced a series of amino-modified 4H-chromene compounds in good yields.
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