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Enhanced Singlet Oxygen Generation via Near‐Infrared Photo‐Activated Upconversion: Application to Amyloid Fibril Degradation

Von Wiley-VCH zur Verfügung gestellt

All in good time: The effects of the solvothermal reaction time on the crystalline phase of polyethylenimine-coated NaYF4 : Yb3+/Er3+ upconversion nanoparticles (UCNPs) were studied. Reaction time prolongation was effective in increasing the ratio of green (2H11/2 and 4S3/24I15/2) to red (4F9/24I15/2) emission (G/R ratio) without morphological changes as well as the α- to β- phase conversion. This resulted in a high quantum yield of upconversion and an appropriate G/R ratio for the photosensitization of singlet oxygen generation. Consequently, the efficiency of the amyloid fibril decomposition cascade was enhanced.


Abstract

In this study, we attempted to improve the quantum yield of upconversion nanoparticles to achieve high efficiency of amyloid fibril decomposition cascade induced by near-infrared-active upconversion nanoparticles complexed with photosensitizers. The effects of the solvothermal reaction time on the crystalline phase of polyethylenimine-coated NaYF4 : Yb3+/Er3+ were studied, while maintaining constant reaction temperature and concentration of the dopants Yb3+ and Er3+. We found that an increased reaction time resulted in the conversion of the crystalline phase from the cubic α- to hexagonal β-forms with a higher upconversion quantum yield. In addition, the prolonged reaction time effectively increased the ratio of green (2H11/2 and 4S3/24I15/2) to red (4F9/24I15/2) emissions, increasing the 1O2 generation via photosensitization to approximately 10 times that of conventional ones. Consequently, the efficiency of the amyloid fibril decomposition cascade induced by upconversion nanoparticles complexed with photosensitizers was improved.

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