Transition metal-catalyzed difunctionalization of activated alkenes has been well developed. However, the enantioselective dicarbofunctionalization of alkenes, especially unactivated alkenes, remains rare. This concept summarizes the recent advances in Ni-catalyzed asymmetric three-component dicarbofunctionalization of alkenes, which is timely and highly desirable for this field.
Asymmetric multicomponent reactions are considered as efficient protocols for constructing complex chiral molecules because of their step- and atom-economy. Nickel-catalyzed asymmetric three-component dicarbofunctionalization of alkenes has been well developed in recent years, which is used in the area of total synthesis of natural products and late-stage modification of drugs because of the rapid incorporation of chiral sp3-enriched carbon centers. In this concept, the significant breakthroughs of this field are summarized, together with the related mechanisms. Moreover, the remaining challenges and potential opportunities of multicomponent dicarbofunctionalization are also highlighted.Zum Volltext