Two catalytic transfer hydrogenation (CTH) routes of alditol production using biomass-derived sugars as the hydrogen donors in the aqueous solution, achieving a considerable yield of alditol and high hydrogen utilization ratio.
Artikel
Enantioselective Ni‐Catalyzed Three‐Component Dicarbofunctionalization of Alkenes
Von Wiley-VCH zur Verfügung gestellt
Transition metal-catalyzed difunctionalization of activated alkenes has been well developed. However, the enantioselective dicarbofunctionalization of alkenes, especially unactivated alkenes, remains rare. This concept summarizes the recent advances in Ni-catalyzed asymmetric three-component dicarbofunctionalization of alkenes, which is timely and highly desirable for this field.
Abstract
Asymmetric multicomponent reactions are considered as efficient protocols for constructing complex chiral molecules because of their step- and atom-economy. Nickel-catalyzed asymmetric three-component dicarbofunctionalization of alkenes has been well developed in recent years, which is used in the area of total synthesis of natural products and late-stage modification of drugs because of the rapid incorporation of chiral sp3-enriched carbon centers. In this concept, the significant breakthroughs of this field are summarized, together with the related mechanisms. Moreover, the remaining challenges and potential opportunities of multicomponent dicarbofunctionalization are also highlighted.
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