Gesellschaft Deutscher Chemiker
Keine Benachrichtigungen
Sie haben noch keine Lesezeichen
Abmelden

Artikel

Efficient Construction of Tetracyclic 1,2,4‐Triazoline‐Fused Dibenzo[b,f][1,4]oxazepines through KI/TBHP‐Mediated [3+2] Annulation between DBO‐Imines and N‐Tosylhydrazones

Von Wiley-VCH zur Verfügung gestellt

A straightforward protocol for 1,2,4-triazoline-fused dibenzo[b,f][1,4]oxazepines is effectively established through KI/TBHP-promoted [3+2] annulation between dibenzo[b,f][1,4]oxazepine-imines and N-tosylhydrazones under mild conditions. The produced 1,2,4-triazoline-fused DBOs could be easily converted into biologically interesting 1,2,4-triazolo-fused DBOs with excellent yields


Abstract

The KI/TBHP (tert-butyl hydroperoxide) promoted [3+2] annulation between dibenzo[b,f][1,4]oxazepine-imines (DBO-Imines) and N-tosylhydrazones under mild conditions has been developed, affording a direct and high atom-economical preparation for tetracyclic 1,2,4-triazoline-fused dibenzo[b,f][1,4]oxazepines (DBOs) in good to excellent yields. This procedure could tolerate a wide range of functional groups and could also be conveniently conducted on a gram-scale reaction, even in a one-pot fashion. The produced 1,2,4-triazoline-fused DBOs could be easily converted into biologically interesting 1,2,4-triazolo-fused DBOs under the action of NBS (N-bromosuccinimide).

Zum Volltext

Überprüfung Ihres Anmeldestatus ...

Wenn Sie ein registrierter Benutzer sind, zeigen wir in Kürze den vollständigen Artikel.