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Effective magnesium‐catalyzed hydroboration of nitriles and imines

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The reduction of stable functional groups such as nitriles into amines under eco-friendly conditions is an important conversion process in organic synthesis. The effective hydroboration of nitriles and imines with pinacolborane using ethoxymagnesium chloride was demonstrated under solvent-free conditions at room temperature. A variety of nitriles and imines were converted into the corresponding amines in excellent yields. In addition, the chemoselective hydroboration of nitriles over alkenes and alkynes was reported in good yields. Furthermore, a suitable reaction mechanism for nitrile hydroboration was proposed based on density functional theory calculations.

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