In this work, the direct conjugation of unprotected glycosyl diselenides with various biomolecules, including resorcinol, resveratrol, as well as the antitumor agent gimeracil, is reported. The Se-aglycon could be oxidatively cleaved from the sug...
![Diastereoselective Synthesis of Pyrazolo[1,2‐a][1,2,4]triazine Derivatives via Cross‐1,3‐dipolar Cyclizations of Azaoxyallyl Cations with N,N′‐Cyclic Azomethine Imines](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/d2fc3c3a-b1e4-467b-bb2f-ac505d3c3ec5/ejoc202300450-toc-0001-m.png)
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Diastereoselective Synthesis of Pyrazolo[1,2‐a][1,2,4]triazine Derivatives via Cross‐1,3‐dipolar Cyclizations of Azaoxyallyl Cations with N,N′‐Cyclic Azomethine Imines
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Pyrazolo[1,2-a][1,2,4]triazine derivatives were synthesized in good yields and excellent diastereoselectivities.via cross-1,3-dipolar cyclizations of α-halohydroxamates (in situ generated azaoxyallyl cations) with N,N′-cyclic azomethine imines under mild metal-free conditions.
Abstract
A cross-1,3-dipolar cycloaddition reaction of α-halohydroxamates (in situ generated azaoxyallyl cations) with N,N′-cyclic azomethine imines was developed. The synthetic protocol provided facile and rapid access to pyrazolo[1,2-a][1,2,4]triazine derivatives in good yields and excellent diastereoselectivities under mild metal-free conditions.
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