Flunitrazepam (FLU) is a highly potent benzodiazepine drug with sedative, hypnotic, and amnestic effects, typically highly associated with violent behavior and drug rape cases. Therefore, the detection of FLU and its metabolites is of great significance in forensic medicine and drug toxicology. This article collates the mechanism of action and drug metabolism of FLU, and summarizes various published methods for the determination of FLU.
Flunitrazepam, a very potent benzodiazepine with sedative, hypnotic and amnesic effects, is commonly used to treat severe insomnia and as an anesthetic. Due to these characteristics, when flunitrazepam is sneaked into alcohol or drinks, it is often highly associated with violent behavior and drug rape cases. Therefore, it is also known as a “date rape drug”, and the detection of flunitrazepam and its metabolites is of great interest in forensic medicine and pharmacotoxicology. This paper describes the mechanism of action and drug metabolism process of flunitrazepam, reviews the different methods for detecting flunitrazepam published over the years, summarizes the detection limits of each method and compares their advantages and disadvantages. We hope to provide some inspiration for future research in this field.Zum Volltext