Steroids are highly prevalent structures in small molecule therapeutics, with the level of oxidation being key to their biological activity and physicochemical properties. These C(sp3)-rich tetracycles contain many stereocentres, which are importa...
Artikel
Deoxygenative Radical Boration of Inert Amides via a Combination of Relay and Cooperative Catalysis
Von Wiley-VCH zur Verfügung gestellt
“The boryl radical generated in situ is used as a type of reactive functionalization agent instead of traditional nucleophiles… thus effectively overcoming the limitation of C-based functionalization reagents to deliver highly valuable α-boryl amines from amides.” This and more about the story behind the front cover can be found in the article at 10.1002/chem.202301199).
Abstract
Invited for the cover of this issue is the group of Prof. Xiaoming Wang at the Shanghai Institute of Organic Chemistry and Hangzhou Institute for Advanced Study, University of the Chinese Academy of Sciences. The image depicts a combination of relay and cooperative catalysis with a triple iridium–photoredox–organocatalysis system to achieve an unprecedented reductive boration of amides. Read the full text of the article at 10.1002/chem.202301199.
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