An efficient method has been developed to achieve solvent-directed diastereodivergent cyclization reactions with quaternary center formation. A series of products were obtained with good yields and diastereoselectivities.
Artikel
BF3 ⋅ Et2O‐Mediated Annulation of 2‐Alkynyl Biaryls with N‐(Arylthio) Succinimides: An Efficient Approach to Access 9‐Sulfenylphenanthrenes
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A simple and effective method for the synthesis of 9-sulfenylphenanthrenes was developed. The reaction proceeds through BF3 ⋅ OEt2-mediated annulation of 2-alkynyl biaryls with N-arylthio succinimides at room temperature. With this method, a series of 9-sulfenylphenanthrenes was efficiently obtained in good to excellent yields under mild and metal-free conditions.
Abstract
A simple and effective method for the synthesis of 9-sulfenylphenanthrenes was developed via BF3 ⋅ OEt2-mediated annulation of 2-alkynyl biaryls with N-arylthio succinimides at room temperature. Through this methodology, a series of 9-sulfenylphenanthrenes could be efficiently and conveniently obtained in good to excellent yields under mild and metal-free conditions.
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